Osmosis Jones is a 2001 American live-action/animated action comedy adventure film with animated scenes directed by Tom Sito and Piet Kroon with live-action scenes directed by the Farrelly Brothers.


A hot-shot policeman white blood cell, with the help of a by-the-books cold pill, must stop a deadly virus from destroying the human they live in, Frank.

Why It Rocks

  1. This, along with another Warner Bros. production The Iron Giant, is a beautifully animated feature film with refreshingly smooth and visually stunning cel-animation with expressive movements and fast-paced action sequences.
  2. The way the inside of the body is essentially a city; the white blood cells are the police, fireman, etc., the lymph nodes were the police stations, veins were highways, the stomach was a bus station/airport type place, and the germs and bacteria were, of course, the criminals, and so on.
  3. A star-studded voice cast provided by Chris Rock, Brandy Norwood, Laurence Fishburne, David Hyde Pierce and William Shatner. 
  4. Thrax, voiced by Laurence Fishburne, is one of the slickest animated antagonists in a kids' film; He is cunning, witty, ruthless to the point of committing on-screen acts of murder, managing to surpass the 'hero' multiple times, and is well-design/voiced/and animated.
  5. The film expertly blends live-action and animation in a unique fashion, especially for the final act.
  6. Marc Hyman wrote a fun, imaginative and adventurous script for the movie.
  7. Bobby and Peter Farrelly did a fine job directing the film, making you suspend reality and imagining your body working like it is depicted in the film.
  8. The film uses and mentions a lot of real-world biological/hygienic terms as characters, backgrounds, and gags, resulting in the film being somewhat educational and thus being used in school.

Bad Qualities

  1. Just like The Iron Giant, the film was a major box-office bomb due to Warner Bros.'s poor marketing and promotion.
  2. Like in many other Farrelly Brothers' movies, it features a lot of gross-out humor and innuendos that exceeds far beyond it's PG rating.
  3. Bill Murray's performance can get pretty lethargic at times, sometimes being unlikable.
  4. The music doesn't really match with some scenes. 
  5. Despite an imaginative concept and premise, the film uses a lot of buddy cop movie cliches.
  6. Both Ebert and Siskel dispsed the film by giving it two thumbs down.